Motivation
Spinal cord injury (SCI) disrupts communication between the brain and body, often impairing autonomic functions like bladder control in addition to motor abilities. Recovery of these functions is critical for improving quality of life in SCI patients, yet effective, accessible therapies remain limited. The Texas Biomedical Device Center (TxBDC) is working to address this by developing neuromodulation-based interventions that promote functional recovery through targeted neuroplasticity. While much of the Center’s clinical focus has emphasized upper and lower limb rehabilitation, bladder function—especially in the context of SCI—presents a vital, often-overlooked application for neuromodulation strategies like vagus nerve stimulation (VNS).
Our Solution
In preclinical studies, TxBDC has explored the use of VNS to facilitate recovery of bladder function following SCI. These studies used a rodent model to evaluate whether precisely timed VNS, delivered during spontaneous bladder activity, could enhance neuroplasticity in circuits responsible for micturition. During behavioral sessions, bladder pressure was monitored in real time, and VNS was manually triggered during voiding events based on electrophysiological cues and pressure surges. These sessions aimed to test whether this stimulation protocol could modulate autonomic function and support functional recovery. This foundational work contributes to the development of eventual closed-loop VNS systems for human use, where stimulation would be autonomously timed based on physiological feedback.
My Contributions
In this project, I was involved in the day-to-day execution of preclinical spinal cord injury studies focused on bladder function recovery through vagus nerve stimulation (VNS). I was responsible for delivering stimulation in real time during voiding events by monitoring bladder pressure and electrophysiological signals, ensuring accurate timing aligned with spontaneous physiological activity. I also fabricated essential neural interface components—including microfabricated cuffs, headcaps, and cables—that were used during surgical implantation. Beyond experimental execution, I conducted routine health monitoring for over 60 lab animals, including tracking weight, detecting tumors, checking for overgrooming, and documenting general well-being. I played a key role in maintaining high standards of animal care, device reliability, and data consistency—supporting both the scientific and ethical integrity of the study.
Project Outcomes
Looking to discuss further? Contact me at research@mkmaharana.com
